Myles Garrett, A.J. Brown, Sam Darnold Sidelined After Week 1 Injuries
Following Week 1 of the 2026 NFL season, multiple star players are sidelined with lower-body injuries. Myles Garrett (2025 NFL Defensive Player of the Year) was placed on injured reserve after knee surgery. A.J. Brown suffered a high right ankle sprain and is also on injured reserve. Sam Darnold, the Seahawks' starting quarterback, sustained a hip injury but is expected to miss short-term. Kyler Murray entered concussion protocol after a hit by Packers safety Javon Bullard.
Week 1 of the 2026 NFL season left multiple marquee players on the sideline heading into Week 2. Myles Garrett, who earned 2025 NFL Defensive Player of the Year honors, was placed on injured reserve, meaning he will miss at least four games. According to CBS Sports, Garrett missed most of training camp with swelling in his knee, including a joint practice against the Dallas Cowboys. He produced just his fourth career game without a tackle on 39 defensive snaps against the San Francisco 49ers in Week 1, his first such game since Week 11 of the 2024 season, per CBS Sports. Garrett racked up an NFL single-season record 23.0 sacks in the 2025 season. Rams head coach Sean McVay told CBS Sports that there will not be a timeline for Garrett's absence until after surgery scheduled for Monday. Garrett will be 31 years old on December 29. The Rams acquired Garrett by trading away Pro Bowl edge rusher Jared Verse, their 2027 first-round pick, 2028 second-round pick, and 2029 third-round pick, according to CBS Sports. Future Hall of Famer Aaron Donald came out of retirement on a one-year deal to play with the Rams for the 2026 season, per CBS Sports. A.J. Brown, a three-time Pro Bowl wide receiver, suffered a high right ankle sprain in Week 1 at the defending Super Bowl champion Seattle Seahawks and is now on injured reserve, also out at least four games. The Patriots signed Romeo Doubs, an ex-Green Bay Packers receiver, on a four-year, $68 million contract with a $39 million guarantee this offseason. Doubs went without a catch on three targets, including a drop, in Week 1, per CBS Sports. Patriots quarterback Drake Maye threw three interceptions in Week 1, with one occurring a play after Doubs' drop, according to CBS Sports. The Patriots traded away deep threat Kayshon Boutte prior to the start of the 2026 season, per CBS Sports. Sam Darnold, a two-time Pro Bowl quarterback for the Seahawks, suffered a hip injury on the Seahawks' opening drive of the season. Per ESPN's reporting cited by CBS Sports, Darnold has a "very unique" soft-tissue injury that did not cause structural damage to his hip joint. The Seahawks expect Darnold's sideline time to be short, though he does not have a recovery timeline established yet, according to CBS Sports. Drew Lock is Seattle's backup quarterback. Minnesota Vikings two-time Pro Bowl quarterback Kyler Murray sustained a concussion from a hit by Packers safety Javon Bullard and is able to participate in meetings, with the team taking his health as day-by-day through the NFL's concussion protocol, per CBS Sports. Head coach Kevin O'Connell said Monday that Murray is able to participate in meetings. Other Week 1 injuries include Isiah Pacheco, who won't return to the Detroit Lions until December after needing back surgery, and Philadelphia Eagles Pro Bowl guard Landon Dickerson, who is dealing with multiple issues and is out for the "foreseeable future," according to head coach Nick Sirianni, per Yahoo Sports. Malik Hooker fractured his wrist during the Dallas Cowboys' Week 1 loss to the New York Giants and required surgery, per Yahoo Sports. DeMarvion Overshown suffered a hamstring injury Sunday night for the Cowboys, per Yahoo Sports. Ladd McConkey of the Los Angeles Chargers exited Sunday's loss to the Arizona Cardinals with a rib injury and is labeled day-to-day by head coach Jim Harbaugh, per Yahoo Sports. Zay Flowers left the Baltimore Ravens' game with a hamstring issue, is day-to-day, and his injury is reportedly not considered serious, per Yahoo Sports.
Myles Garrett, A.J. Brown, and Sam Darnold suffered lower-body injuries in Week 1 of the 2026 NFL season, with Garrett and Brown placed on injured reserve for at least four games.
Garrett's four-game minimum absence creates an immediate pass-rush gap for a Rams team that mortgaged future draft capital for his services. Brown's ankle sprain and Darnold's unscheduled hip recovery timeline introduce depth questions for New England and Seattle in their respective opening stretches. Murray's concussion protocol status becomes clear by Week 2 kickoff; whether he clears that window determines Minnesota's offensive stability heading into an early-season stretch.
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